GalT-KO pig lungs are highly susceptible to acute vascular rejection in baboons, which may be mitigated by transgenic expression of hCD47 on porcine blood vessels

BACKGROUND: Despite recent progress in survival times of xenografts in nonhuman primates, there are no reports of survival beyond 5 days of histologically well-aerated porcine lung grafts in baboons. Here we report our initial results of pig-to-baboon xeno lung transplantation (XLTx). METHODS: Eleve...

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Gepubliceerd in:Xenotransplantation
Hoofdauteurs: Watanabe, Hironosuke, Sahara, Hisashi, Nomura, Shunichiro, Tanabe, Tatsu, Ekanayake-Alper, Dilrukshi K, Boyd, Lennan K., Louras, Nathan J., Asfour, Arsenoi, Danton, Makenzie A., Ho, Siu-Hong, Arn, J. Scott, Hawley, Robert J., Shimizu, Akira, Nagayasu, Takeshi, Ayares, David, Lorber, Marc I., Sykes, Megan, Sachs, David H., Yamada, Kazuhiko
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2018
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6135720/
https://ncbi.nlm.nih.gov/pubmed/29527745
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/xen.12391
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