Intra-bone bone marrow transplantation from hCD47 transgenic pigs to baboons prolongs chimerism to >60 days and promotes increased porcine lung transplant survival

BACKGROUND: We have recently demonstrated that human-CD47 (hCD47) expressed on endothelial cells of porcine lung xenografts extended median graft survival from 3.5 days to 8.7 days in baboons. Intra-bone bone marrow transplantation (IBBMTx) in a pig-to-baboon model was previously shown to markedly p...

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Detalhes bibliográficos
Publicado no:Xenotransplantation
Main Authors: Watanabe, Hironosuke, Ariyoshi, Yuichi, Pomposelli, Thomas, Takeuchi, Kazuhiro, Ekanayake-Alper, Dilrukshi K, Boyd, Lennan, Arn, Scott, Sahara, Hisashi, Shimizu, Akira, Ayares, David, Lorber, Marc I., Sykes, Megan, Sachs, David H, Yamada, Kazuhiko
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7007336/
https://ncbi.nlm.nih.gov/pubmed/31544995
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/xen.12552
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