Cobalt hematoporphyrin inhibits CLEC-2–podoplanin interaction, tumor metastasis, and arterial/venous thrombosis in mice

The platelet activation receptor C-type lectin-like receptor 2 (CLEC-2) interacts with podoplanin on the surface of certain types of tumor cells, and this interaction facilitates tumor metastasis. CLEC-2 is also involved in thrombus formation and its stabilization. Because CLEC-2–depleted mice are p...

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Vydáno v:Blood Adv
Hlavní autoři: Tsukiji, Nagaharu, Osada, Makoto, Sasaki, Tomoyuki, Shirai, Toshiaki, Satoh, Kaneo, Inoue, Osamu, Umetani, Norihiko, Mochizuki, Chihiro, Saito, Tamio, Kojima, Soichi, Shinmori, Hideyuki, Ozaki, Yukio, Suzuki-Inoue, Katsue
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society of Hematology 2018
Témata:
Platelets and Thrombopoiesis
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6134222/
https://ncbi.nlm.nih.gov/pubmed/30190281
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/bloodadvances.2018016261
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