A β1-tubulin–based megakaryocyte maturation reporter system identifies novel drugs that promote platelet production

During maturation, megakaryocytes (MKs) express β1-tubulin (TUBB1) and rearrange their microtubule components to enlarge, form proplatelets, and eventually release platelets. The development of a platform to identify in vitro conditions that would efficiently promote MK development could potentially...

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Detalhes bibliográficos
Publicado no:Blood Adv
Main Authors: Seo, Hideya, Chen, Si Jing, Hashimoto, Kazuya, Endo, Hiroshi, Nishi, Yohei, Ohta, Akira, Yamamoto, Takuya, Hotta, Akitsu, Sawaguchi, Akira, Hayashi, Hideki, Koseki, Noritaka, Murphy, George J., Fukuda, Kazuhiko, Sugimoto, Naoshi, Eto, Koji
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2018
Assuntos:
Platelets and Thrombopoiesis
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6134216/
https://ncbi.nlm.nih.gov/pubmed/30206099
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/bloodadvances.2018019547
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