HDAC6 inhibitor TST strengthens the antiproliferative effects of PI3K/mTOR inhibitor BEZ235 in breast cancer cells via suppressing RTK activation

NVP-BEZ235 (BEZ235), an available dual PI3K/mTOR inhibitor, showed antitumor effect and provided a therapy strategy in carcinomas. However, the acquired upregulation of multiple receptor tyrosine kinases (RTKs) by NVP-BEZ235 in tumors limits its clinical efficacy. HDAC6, a class II histone deacetyla...

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Publicado no:Cell Death Dis
Main Authors: Sun, Shixiu, Zhang, Yujie, Zheng, Jianchao, Duan, Biao, Cui, Jie, Chen, Yan, Deng, Wenjie, Ye, Bixing, Liu, Lei, Chen, Yongchang, Du, Jun, Gu, Luo
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6134008/
https://ncbi.nlm.nih.gov/pubmed/30206202
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-018-0931-0
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