NMR-based investigations into target DNA search processes of proteins

To perform their function, transcription factors and DNA-repair/modifying enzymes must first locate their targets in the vast presence of nonspecific, but structurally similar sites on genomic DNA. Before reaching their targets, these proteins stochastically scan DNA and dynamically move from one si...

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Bibliographic Details
Published in:Methods
Main Authors: Iwahara, Junji, Zandarashvili, Levani, Kemme, Catherine A., Esadze, Alexandre
Format: Artigo
Language:Inglês
Published: 2018
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6133758/
https://ncbi.nlm.nih.gov/pubmed/29753002
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ymeth.2018.05.004
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