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An NMR strategy to detect conformational differences in a protein complexed with highly analogous inhibitors in solution
This manuscript presents an NMR strategy to investigate conformational differences in protein-inhibitor complexes, when the inhibitors tightly bind to a protein at sub-nanomolar dissociation constants and are highly analogous to each other. Using HIV-1 protease (PR), we previously evaluated amide ch...
Gardado en:
| Publicado en: | Methods |
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| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2018
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6133750/ https://ncbi.nlm.nih.gov/pubmed/29656080 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ymeth.2018.04.005 |
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