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No Structure-Switching Required: A Generalizable Exonuclease-Mediated Aptamer-Based Assay for Small-Molecule Detection
[Image: see text] The binding of small molecules to double-stranded DNA can modulate its susceptibility to digestion by exonucleases. Here, we show that the digestion of aptamers by exonuclease III can likewise be inhibited upon binding of small-molecule targets and exploit this finding for the firs...
Wedi'i Gadw mewn:
| Cyhoeddwyd yn: | J Am Chem Soc |
|---|---|
| Prif Awduron: | , , , , , |
| Fformat: | Artigo |
| Iaith: | Inglês |
| Cyhoeddwyd: |
2018
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| Pynciau: | |
| Mynediad Ar-lein: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6133295/ https://ncbi.nlm.nih.gov/pubmed/30011200 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.8b04975 |
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