CDK1 inhibition sensitizes normal cells to DNA damage in a cell cycle dependent manner

Cyclin-dependent kinase 1 (CDK1) orchestrates the transition from the G2 phase into mitosis and as cancer cells often display enhanced CDK1 activity, it has been proposed as a tumor specific anti-cancer target. Here we show that the effects of CDK1 inhibition are not restricted to tumor cells but ca...

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Détails bibliographiques
Publié dans:Cell Cycle
Auteurs principaux: Prevo, Remko, Pirovano, Giacomo, Puliyadi, Rathi, Herbert, Katharine J., Rodriguez-Berriguete, Gonzalo, O’Docherty, Alice, Greaves, William, McKenna, W. Gillies, Higgins, Geoff S.
Format: Artigo
Langue:Inglês
Publié: Taylor & Francis 2018
Sujets:
Research Paper
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6132956/
https://ncbi.nlm.nih.gov/pubmed/30045664
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15384101.2018.1491236
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