NUDT15 codon 139 is the best pharmacogenetic marker for predicting thiopurine-induced severe adverse events in Japanese patients with inflammatory bowel disease: a multicenter study

BACKGROUND: Despite NUDT15 variants showing significant association with thiopurine-induced adverse events (AEs) in Asians, it remains unclear which variants of NUDT15 or whether additional genetic variants should be tested to predict AEs. To clarify the best pharmacogenetic test to be used clinical...

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Udgivet i:J Gastroenterol
Main Authors: Kakuta, Yoichi, Kawai, Yosuke, Okamoto, Daisuke, Takagawa, Tetsuya, Ikeya, Kentaro, Sakuraba, Hirotake, Nishida, Atsushi, Nakagawa, Shoko, Miura, Miki, Toyonaga, Takahiko, Onodera, Kei, Shinozaki, Masaru, Ishiguro, Yoh, Mizuno, Shinta, Takahara, Masahiro, Yanai, Shunichi, Hokari, Ryota, Nakagawa, Tomoo, Araki, Hiroshi, Motoya, Satoshi, Naito, Takeo, Moroi, Rintaro, Shiga, Hisashi, Endo, Katsuya, Kobayashi, Taku, Naganuma, Makoto, Hiraoka, Sakiko, Matsumoto, Takayuki, Nakamura, Shiro, Nakase, Hiroshi, Hisamatsu, Tadakazu, Sasaki, Makoto, Hanai, Hiroyuki, Andoh, Akira, Nagasaki, Masao, Kinouchi, Yoshitaka, Shimosegawa, Tooru, Masamune, Atsushi, Suzuki, Yasuo
Format: Artigo
Sprog:Inglês
Udgivet: Springer Japan 2018
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Original Article—Alimentary Tract
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6132901/
https://ncbi.nlm.nih.gov/pubmed/29923122
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00535-018-1486-7
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