Influence of NUDT15 variants on hematological pictures of patients with inflammatory bowel disease treated with thiopurines

AIM: The single nucleotide polymorphism (SNP) c.415C>T in exon 3 of NUDT15 affects thiopurine-induced leukopenia in Asian patients with Crohn’s disease. Meanwhile, three additional genetic variants of NUDT15 were reported in patients with acute lymphoblastic leukemia. We evaluated the effects of...

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Vydáno v:World J Gastroenterol
Hlavní autoři: Kojima, Yuichiro, Hirotsu, Yosuke, Omata, Wataru, Sugimori, Makoto, Takaoka, Shinya, Ashizawa, Hiroshi, Nakagomi, Keiko, Yoshimura, Dai, Hosoda, Kenji, Suzuki, Yoji, Mochizuki, Hitoshi, Omata, Masao
Médium: Artigo
Jazyk:Inglês
Vydáno: Baishideng Publishing Group Inc 2018
Témata:
Observational Study
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5787786/
https://ncbi.nlm.nih.gov/pubmed/29398872
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3748/wjg.v24.i4.511
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