APOBEC3B Activity Is Prevalent in Urothelial Carcinoma Cells and Only Slightly Affected by LINE-1 Expression

The most common mutational signature in urothelial carcinoma (UC), the most common type of urinary bladder cancer is assumed to be caused by the misdirected activity of APOBEC3 (A3) cytidine deaminases, especially A3A or A3B, which are known to normally restrict the propagation of exogenous viruses...

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Bibliographic Details
Published in:Front Microbiol
Main Authors: Jaguva Vasudevan, Ananda Ayyappan, Kreimer, Ulrike, Schulz, Wolfgang A., Krikoni, Aikaterini, Schumann, Gerald G., Häussinger, Dieter, Münk, Carsten, Goering, Wolfgang
Format: Artigo
Language:Inglês
Published: Frontiers Media S.A. 2018
Subjects:
Microbiology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6132077/
https://ncbi.nlm.nih.gov/pubmed/30233553
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fmicb.2018.02088
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