APOBEC3B Activity Is Prevalent in Urothelial Carcinoma Cells and Only Slightly Affected by LINE-1 Expression

The most common mutational signature in urothelial carcinoma (UC), the most common type of urinary bladder cancer is assumed to be caused by the misdirected activity of APOBEC3 (A3) cytidine deaminases, especially A3A or A3B, which are known to normally restrict the propagation of exogenous viruses...

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Détails bibliographiques
Publié dans:Front Microbiol
Auteurs principaux: Jaguva Vasudevan, Ananda Ayyappan, Kreimer, Ulrike, Schulz, Wolfgang A., Krikoni, Aikaterini, Schumann, Gerald G., Häussinger, Dieter, Münk, Carsten, Goering, Wolfgang
Format: Artigo
Langue:Inglês
Publié: Frontiers Media S.A. 2018
Sujets:
Microbiology
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6132077/
https://ncbi.nlm.nih.gov/pubmed/30233553
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fmicb.2018.02088
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