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A novel synthetic trivalent single chain variable fragment (tri-scFv) construction platform based on the SpyTag/SpyCatcher protein ligase system

BACKGROUND: Advances in antibody engineering provide strategies to construct recombinant antibody-like molecules with modified pharmacokinetic properties. Multermerization is one strategy that has been used to produce antibody-like molecules with two or more antigen binding sites. Multimerization en...

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Detalhes bibliográficos
Publicado no:BMC Biotechnol
Main Authors: Alam, Md. Kausar, Brabant, Michelle, Viswas, Raja Solomon, Barreto, Kris, Fonge, Humphrey, Ronald Geyer, C.
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2018
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6131909/
https://ncbi.nlm.nih.gov/pubmed/30200951
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12896-018-0466-6
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