Absence of Sirt3 aggravates cisplatin nephrotoxicity via enhanced renal tubular apoptosis and inflammation

Cisplatin-based chemotherapy is commonly used in the treatment of solid tumors; however, this agent is limited by its adverse effects on normal tissues, including the kidneys, ears and peripheral nerves. Mechanisms of cisplatin nephrotoxicity are proposed to involve oxidative stress, inflammation, c...

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Bibliographic Details
Published in:Mol Med Rep
Main Authors: Kim, Dal, Park, Woong, Lee, Sik, Kim, Won, Park, Sung Kwang, Kang, Kyung Pyo
Format: Artigo
Language:Inglês
Published: D.A. Spandidos 2018
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6131565/
https://ncbi.nlm.nih.gov/pubmed/30106119
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3892/mmr.2018.9350
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