Coupling of a specific photoreactive triple-helical peptide to crosslinked collagen films restores binding and activation of DDR2 and VWF

Collagen-based scaffolds may require chemical crosslinking to achieve mechanical properties suitable for tissue engineering. Carbodiimide treatment, often used for this purpose, consumes amino acid side chains required for receptor recognition, thus reducing cell–collagen interaction. Here, we resto...

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Veröffentlicht in:Biomaterials
Hauptverfasser: Malcor, Jean-Daniel, Juskaite, Victoria, Gavriilidou, Despoina, Hunter, Emma J., Davidenko, Natalia, Hamaia, Samir, Sinha, Sanjay, Cameron, Ruth E., Best, Serena M., Leitinger, Birgit, Farndale, Richard W.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Elsevier Science 2018
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6131271/
https://ncbi.nlm.nih.gov/pubmed/30099278
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.biomaterials.2018.07.050
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