Runx2 is required for the proliferation of osteoblast progenitors and induces proliferation by regulating Fgfr2 and Fgfr3

Runx2 and Sp7 are essential transcription factors for osteoblast differentiation. However, the molecular mechanisms responsible for the proliferation of osteoblast progenitors remain unclear. The early onset of Runx2 expression caused limb defects through the Fgfr1–3 regulation by Runx2. To investig...

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Publicado en:Sci Rep
Autores principales: Kawane, Tetsuya, Qin, Xin, Jiang, Qing, Miyazaki, Toshihiro, Komori, Hisato, Yoshida, Carolina Andrea, Matsuura-Kawata, Viviane Keiko dos Santos, Sakane, Chiharu, Matsuo, Yuki, Nagai, Kazuhiro, Maeno, Takafumi, Date, Yuki, Nishimura, Riko, Komori, Toshihisa
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Publishing Group UK 2018
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6131145/
https://ncbi.nlm.nih.gov/pubmed/30202094
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-31853-0
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