Runx2 is required for the proliferation of osteoblast progenitors and induces proliferation by regulating Fgfr2 and Fgfr3

Runx2 and Sp7 are essential transcription factors for osteoblast differentiation. However, the molecular mechanisms responsible for the proliferation of osteoblast progenitors remain unclear. The early onset of Runx2 expression caused limb defects through the Fgfr1–3 regulation by Runx2. To investig...

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Vydáno v:Sci Rep
Hlavní autoři: Kawane, Tetsuya, Qin, Xin, Jiang, Qing, Miyazaki, Toshihiro, Komori, Hisato, Yoshida, Carolina Andrea, Matsuura-Kawata, Viviane Keiko dos Santos, Sakane, Chiharu, Matsuo, Yuki, Nagai, Kazuhiro, Maeno, Takafumi, Date, Yuki, Nishimura, Riko, Komori, Toshihisa
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2018
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6131145/
https://ncbi.nlm.nih.gov/pubmed/30202094
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-31853-0
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