Runx2 is required for the proliferation of osteoblast progenitors and induces proliferation by regulating Fgfr2 and Fgfr3

Runx2 and Sp7 are essential transcription factors for osteoblast differentiation. However, the molecular mechanisms responsible for the proliferation of osteoblast progenitors remain unclear. The early onset of Runx2 expression caused limb defects through the Fgfr1–3 regulation by Runx2. To investig...

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發表在:Sci Rep
Main Authors: Kawane, Tetsuya, Qin, Xin, Jiang, Qing, Miyazaki, Toshihiro, Komori, Hisato, Yoshida, Carolina Andrea, Matsuura-Kawata, Viviane Keiko dos Santos, Sakane, Chiharu, Matsuo, Yuki, Nagai, Kazuhiro, Maeno, Takafumi, Date, Yuki, Nishimura, Riko, Komori, Toshihisa
格式: Artigo
語言:Inglês
出版: Nature Publishing Group UK 2018
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Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC6131145/
https://ncbi.nlm.nih.gov/pubmed/30202094
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-31853-0
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