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Rational Design of Thiolase Substrate Specificity for Metabolic Engineering Applications

Metabolic engineering efforts require enzymes that are both highly active and specific towards the synthesis of a desired output product in order to be commercially feasible. The 3-hydroxyacid pathway (3HA), also known as the reverse β-oxidation (r-BOX) or coenzyme-A dependent chain elongation pathw...

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Publicado en:Biotechnol Bioeng
Autores principales: Bonk, Brian M., Tarasova, Yekaterina, Hicks, Michael A., Tidor, Bruce, Prather, Kristala L.J.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2018
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6131064/
https://ncbi.nlm.nih.gov/pubmed/29877597
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/bit.26737
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