The rational design of affinity-attenuated OmCI for the purification of complement C5

Complement component C5 is the target of the mAb eculizumab and is the focus of a sustained drug discovery effort to prevent complement-induced inflammation in a range of autoimmune diseases. The immune evasion protein OmCI binds to and potently inactivates C5; this tight-binding interaction can be...

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Bibliografische gegevens
Gepubliceerd in:J Biol Chem
Hoofdauteurs: Macpherson, Alex, Liu, Xiaofeng, Dedi, Neesha, Kennedy, Jeffery, Carrington, Bruce, Durrant, Oliver, Heywood, Sam, van den Elsen, Jean, Lawson, Alastair D. G.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Society for Biochemistry and Molecular Biology 2018
Onderwerpen:
Methods and Resources
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6130949/
https://ncbi.nlm.nih.gov/pubmed/30030376
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.004043
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