Oligomerization Alters Binding Affinity Between Amyloid Beta and a Modulator of Peptide Aggregation

The soluble oligomeric form of the amyloid beta (Aβ) peptide is the major causative agent in the molecular pathogenesis of Alzheimer’s disease (AD). We have previously developed a pyrroline-nitroxyl fluorene compound (SLF) that blocks the toxicity of Aβ. Here we introduce the multi-parametric surfac...

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Detaylı Bibliyografya
Yayımlandı:J Phys Chem C Nanomater Interfaces
Asıl Yazarlar: Hilt, Silvia, Rojalin, Tatu, Viitala, Tapani, Koivuniemi, Artturi, Bunker, Alex, Hogiu, Sebastian Wachsmann, Kálai, Tamás, Hideg, Kálmán, Yliperttula, Marjo, Voss, John C.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2017
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC6130836/
https://ncbi.nlm.nih.gov/pubmed/30214656
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jpcc.7b06164
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