Chalcones and Five-Membered Heterocyclic Isosteres Bind to Alpha Synuclein Fibrils in Vitro

[Image: see text] A series of chalcone and heterocyclic isosteres, in which the enone moiety was replaced with an isoxazole and pyrazole ring system, was synthesized and their affinities for alpha synuclein (Asyn), amyloid beta (Aβ), and tau fibrils were measured in vitro. The compounds were found t...

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Detaylı Bibliyografya
Yayımlandı:ACS Omega
Asıl Yazarlar: Hsieh, Chia-Ju, Xu, Kuiying, Lee, Iljung, Graham, Thomas J. A., Tu, Zhude, Dhavale, Dhruva, Kotzbauer, Paul, Mach, Robert H.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Chemical Society 2018
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC6130786/
https://ncbi.nlm.nih.gov/pubmed/30221226
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsomega.7b01897
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