Structural basis of RNA polymerase I stalling at UV light-induced DNA damage

RNA polymerase I (Pol I) transcribes ribosomal DNA (rDNA) to produce the ribosomal RNA (rRNA) precursor, which accounts for up to 60% of the total transcriptional activity in growing cells. Pol I monitors rDNA integrity and influences cell survival, but little is known about how this enzyme processe...

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Detalles Bibliográficos
Publicado en:Proc Natl Acad Sci U S A
Autores principales: Sanz-Murillo, Marta, Xu, Jun, Belogurov, Georgiy A., Calvo, Olga, Gil-Carton, David, Moreno-Morcillo, María, Wang, Dong, Fernández-Tornero, Carlos
Formato: Artigo
Lenguaje:Inglês
Publicado: National Academy of Sciences 2018
Materias:
Biological Sciences
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6130403/
https://ncbi.nlm.nih.gov/pubmed/30127008
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1802626115
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