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Mutational signature distribution varies with DNA replication timing and strand asymmetry
BACKGROUND: DNA replication plays an important role in mutagenesis, yet little is known about how it interacts with other mutagenic processes. Here, we use somatic mutation signatures—each representing a mutagenic process—derived from 3056 patients spanning 19 cancer types to quantify the strand asy...
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| Vydáno v: | Genome Biol |
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| Hlavní autoři: | , , , |
| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
BioMed Central
2018
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6130095/ https://ncbi.nlm.nih.gov/pubmed/30201020 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13059-018-1509-y |
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