Structural Basis for the Inhibition of Cyclin G‐Associated Kinase by Gefitinib

Gefitinib is the molecular target drug for advanced non‐small‐cell lung cancer. The primary target of gefitinib is the positive mutation of epidermal growth factor receptor, but it also inhibits cyclin G‐associated kinase (GAK). To reveal the molecular bases of GAK and gefitinib binding, structure a...

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Vydáno v:ChemistryOpen
Hlavní autoři: Ohbayashi, Naomi, Murayama, Kazutaka, Kato‐Murayama, Miyuki, Kukimoto‐Niino, Mutsuko, Uejima, Tamami, Matsuda, Takayoshi, Ohsawa, Noboru, Yokoyoma, Shigeyuki, Nojima, Hiroshi, Shirouzu, Mikako
Médium: Artigo
Jazyk:Inglês
Vydáno: John Wiley and Sons Inc. 2018
Témata:
Full Papers
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6129943/
https://ncbi.nlm.nih.gov/pubmed/30214852
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/open.201800177
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