Structural Basis for the Inhibition of Cyclin G‐Associated Kinase by Gefitinib

Gefitinib is the molecular target drug for advanced non‐small‐cell lung cancer. The primary target of gefitinib is the positive mutation of epidermal growth factor receptor, but it also inhibits cyclin G‐associated kinase (GAK). To reveal the molecular bases of GAK and gefitinib binding, structure a...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:ChemistryOpen
Prif Awduron: Ohbayashi, Naomi, Murayama, Kazutaka, Kato‐Murayama, Miyuki, Kukimoto‐Niino, Mutsuko, Uejima, Tamami, Matsuda, Takayoshi, Ohsawa, Noboru, Yokoyoma, Shigeyuki, Nojima, Hiroshi, Shirouzu, Mikako
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: John Wiley and Sons Inc. 2018
Pynciau:
Full Papers
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC6129943/
https://ncbi.nlm.nih.gov/pubmed/30214852
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/open.201800177
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