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Structural Basis for the Inhibition of Cyclin G‐Associated Kinase by Gefitinib
Gefitinib is the molecular target drug for advanced non‐small‐cell lung cancer. The primary target of gefitinib is the positive mutation of epidermal growth factor receptor, but it also inhibits cyclin G‐associated kinase (GAK). To reveal the molecular bases of GAK and gefitinib binding, structure a...
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| Vydáno v: | ChemistryOpen |
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| Hlavní autoři: | , , , , , , , , , |
| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
John Wiley and Sons Inc.
2018
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6129943/ https://ncbi.nlm.nih.gov/pubmed/30214852 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/open.201800177 |
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