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A Mitochondrial Uncoupling Prodrug Improves Tissue Sparing, Cognitive Outcome and Mitochondrial Bioenergetics after Traumatic Brain Injury in Male Mice

Traumatic brain injury (TBI) results in cognitive impairment, which can be long-lasting after moderate to severe TBI. Currently, there are no FDA-approved therapeutics to treat the devastating consequences of TBI and improve recovery. This study utilizes a prodrug of 2,4-dinitrophenol (DNP), MP201,...

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Detalhes bibliográficos
Publicado no:J Neurosci Res
Main Authors: Hubbard, W. Brad, Harwood, Christopher L., Geisler, John G., Vekaria, Hemendra J., Sullivan, Patrick G.
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6129401/
https://ncbi.nlm.nih.gov/pubmed/30063076
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jnr.24271
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