Sequestration of T-cells in bone marrow in the setting of glioblastoma and other intracranial tumors

T-cell dysfunction contributes to tumor immune escape in patients with cancer and is particularly severe amidst glioblastoma (GBM). Among other defects, T-cell lymphopenia is characteristic, yet often attributed to treatment. We reveal that even treatment-naïve patients and mice with GBM can harbor...

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Detaylı Bibliyografya
Yayımlandı:Nat Med
Asıl Yazarlar: Chongsathidkiet, Pakawat, Jackson, Christina, Koyama, Shohei, Loebel, Franziska, Cui, Xiuyu, Farber, S. Harrison, Woroniecka, Karolina, Elsamadicy, Aladine A., Dechant, Cosette A., Kemeny, Hanna R., Sanchez-Perez, Luis, Cheema, Tooba A., Souders, Nicholas C., Herndon, James E., Coumans, Jean-Valery, Everitt, Jeffrey I., Nahed, Brian V., Sampson, John H., Gunn, Michael D., Martuza, Robert L., Dranoff, Glenn, Curry, William T., Fecci, Peter E.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2018
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC6129206/
https://ncbi.nlm.nih.gov/pubmed/30104766
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41591-018-0135-2
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