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Serum-derived carcinoembryonic antigen (CEA) activates fibroblasts to induce a local re-modeling of the extracellular matrix that favors the engraftment of CEA-expressing tumor cells

Elevated levels of the carcinoembryonic antigen (CEA; CEACAM5) in the serum of colorectal cancer (CRC) patients represent a clinical biomarker that correlates with disease recurrence. However, a mechanistic role for soluble CEA (sCEA) in tumor progression and metastasis remains to be established. In...

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Bibliografiske detaljer
Udgivet i:Int J Cancer
Main Authors: Abdul-Wahid, Aws, Cydzik, Marzena, Fischer, Nicholas W., Prodeus, Aaron, Shively, John E, Martel, Anne, Alminawi, Samira, Ghorab, Zeina, Berinstein, Neil L., Gariépy, Jean
Format: Artigo
Sprog:Inglês
Udgivet: 2018
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6128780/
https://ncbi.nlm.nih.gov/pubmed/29756328
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/ijc.31586
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