Autocrine Mfge8 signaling prevents developmental exhaustion of the adult neural stem cell pool

Adult neurogenesis, arising from quiescent radial-glia like neural stem cells (RGLs), occurs throughout life in the dentate gyrus. How neural stem cells are maintained throughout development to sustain adult mammalian neurogenesis is not well understood. Here we show that Milk Fat Globule-EGF 8 (Mfg...

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Veröffentlicht in:Cell Stem Cell
Hauptverfasser: Zhou, Yi, Bond, Allison M., Shade, Jamie E., Zhu, Yunhua, Davis, Chung-ha O., Wang, Xinyuan, Su, Yijing, Yoon, Ki-Jun, Phan, Alexander T., Chen, William J., Oh, Justin H., Marsh-Armstrong, Nicholas, Atabai, Kamran, Ming, Guo-li, Song, Hongjun
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2018
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6128767/
https://ncbi.nlm.nih.gov/pubmed/30174295
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stem.2018.08.005
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