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Poly (ADP-ribose) prevents pathological phase separation of TDP-43 by promoting liquid demixing and stress-granule localization
In amyotrophic lateral sclerosis (ALS) and frontotemporal degeneration (FTD), cytoplasmic aggregates of hyperphosphorylated TDP-43 accumulate and colocalize with some stressgranule components, but how pathological TDP-43 aggregation is nucleated remains unknown. In Drosophila, we establish that down...
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| Publicat a: | Mol Cell |
|---|---|
| Autors principals: | , , , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2018
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6128762/ https://ncbi.nlm.nih.gov/pubmed/30100264 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2018.07.002 |
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