Poly(ADP-ribose) Engages the TDP-43 Nuclear-Localization Sequence to Regulate Granulo-Filamentous Aggregation

[Image: see text] TAR DNA-binding protein of 43 kDa (TDP-43) forms granulo-filamentous aggregates in affected brain regions of >95% of patients with ALS and ∼50% of patients with frontotemporal degeneration (FTD). Furthermore, in disease, TDP-43 becomes N-terminally truncated resulting in protein...

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Bibliographic Details
Published in:Biochemistry
Main Authors: McGurk, Leeanne, Gomes, Edward, Guo, Lin, Shorter, James, Bonini, Nancy M.
Format: Artigo
Language:Inglês
Published: American Chemical Society 2018
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6752045/
https://ncbi.nlm.nih.gov/pubmed/30540446
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.8b00910
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