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Poly(ADP-ribose) Engages the TDP-43 Nuclear-Localization Sequence to Regulate Granulo-Filamentous Aggregation
[Image: see text] TAR DNA-binding protein of 43 kDa (TDP-43) forms granulo-filamentous aggregates in affected brain regions of >95% of patients with ALS and ∼50% of patients with frontotemporal degeneration (FTD). Furthermore, in disease, TDP-43 becomes N-terminally truncated resulting in protein...
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| Udgivet i: | Biochemistry |
|---|---|
| Main Authors: | , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
American
Chemical Society
2018
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| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6752045/ https://ncbi.nlm.nih.gov/pubmed/30540446 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.8b00910 |
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