TBK1 suppresses RIPK1-driven apoptosis and inflammation during development and in aging

Aging is a major risk factor for both genetic and sporadic neurodegenerative disorders. However, it is unclear how aging interacts with genetic predispositions to promote neurodegeneration. Here we investigate how partial loss-of-function of TBK1, a major genetic cause for amyotrophic lateral sclero...

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Publicat a:Cell
Autors principals: Xu, Daichao, Jin, Taijie, Zhu, Hong, Chen, Hongbo, Ofengeim, Dimitry, Zou, Chengyu, Mifflin, Lauren, Pan, Lifeng, Amin, Palak, Li, Wanjin, Shan, Bing, Naito, Masanori Gomi, Meng, Huyan, Li, Ying, Pan, Heling, Aron, Liviu, Adiconis, Xian, Levin, Joshua Z., Yankner, Bruce A, Yuan, Junying
Format: Artigo
Idioma:Inglês
Publicat: 2018
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6128749/
https://ncbi.nlm.nih.gov/pubmed/30146158
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2018.07.041
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