tp53 deficiency causes a wide tumor spectrum and increases embryonal rhabdomyosarcoma metastasis in zebrafish

The TP53 tumor-suppressor gene is mutated in >50% of human tumors and Li-Fraumeni patients with germ line inactivation are predisposed to developing cancer. Here, we generated tp53 deleted zebrafish that spontaneously develop malignant peripheral nerve-sheath tumors, angiosarcomas, germ cell tumo...

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Pubblicato in:eLife
Autori principali: Ignatius, Myron S, Hayes, Madeline N, Moore, Finola E, Tang, Qin, Garcia, Sara P, Blackburn, Patrick R, Baxi, Kunal, Wang, Long, Jin, Alexander, Ramakrishnan, Ashwin, Reeder, Sophia, Chen, Yidong, Nielsen, Gunnlaugur Petur, Chen, Eleanor Y, Hasserjian, Robert P, Tirode, Franck, Ekker, Stephen C, Langenau, David M
Natura: Artigo
Lingua:Inglês
Pubblicazione: eLife Sciences Publications, Ltd 2018
Soggetti:
Cancer Biology
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6128690/
https://ncbi.nlm.nih.gov/pubmed/30192230
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.37202
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