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In vivo imaging of tumor-propagating cells, regional tumor heterogeneity, and dynamic cell movements in embryonal rhabdomyosarcoma

Embryonal rhabdomyosarcoma (ERMS) is an aggressive pediatric sarcoma of muscle. Here, we show that ERMS-propagating potential is confined to myf5+ cells and can be visualized in live, fluorescent transgenic zebrafish. During early tumor growth, myf5+ ERMS cells reside adjacent normal muscle fibers....

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Detalhes bibliográficos
Main Authors: Ignatius, Myron S., Chen, Eleanor, Elpek, Natalie M., Fuller, Adam, Tenente, Inês M., Clagg, Ryan, Liu, Sali, Blackburn, Jessica S., Linardic, Corinne M., Rosenberg, Andrew, Nielsen, Petur G., Mempel, Thorsten R., Langenau, David M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3381357/
https://ncbi.nlm.nih.gov/pubmed/22624717
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccr.2012.03.043
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