Blood-induced bone loss in murine hemophilic arthropathy is prevented by blocking the iRhom2/ADAM17/TNF-α pathway

Hemophilic arthropathy (HA) is a debilitating degenerative joint disease that is a major manifestation of the bleeding disorder hemophilia A. HA typically begins with hemophilic synovitis that resembles inflammatory arthritides, such as rheumatoid arthritis, and frequently results in bone loss in pa...

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Veröffentlicht in:Blood
Hauptverfasser: Haxaire, Coline, Hakobyan, Narine, Pannellini, Tania, Carballo, Camila, McIlwain, David, Mak, Tak W., Rodeo, Scott, Acharya, Suchitra, Li, Daniel, Szymonifka, Jackie, Song, Xiangqian, Monette, Sébastien, Srivastava, Alok, Salmon, Jane E., Blobel, Carl P.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society of Hematology 2018
Schlagworte:
Thrombosis and Hemostasis
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6128089/
https://ncbi.nlm.nih.gov/pubmed/29776906
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2017-12-820571
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