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Glutamine via α-ketoglutarate dehydrogenase provides succinyl-CoA for heme synthesis during erythropoiesis

During erythroid differentiation, the erythron must remodel its protein constituents so that the mature red cell contains hemoglobin as the chief cytoplasmic protein component. For this, ∼10(9) molecules of heme must be synthesized, consuming 10(10) molecules of succinyl-CoA. It has long been assume...

תיאור מלא

שמור ב:
מידע ביבליוגרפי
הוצא לאור ב:Blood
Main Authors: Burch, Joseph S., Marcero, Jason R., Maschek, John Alan, Cox, James E., Jackson, Laurie K., Medlock, Amy E., Phillips, John D., Dailey, Harry A.
פורמט: Artigo
שפה:Inglês
יצא לאור: American Society of Hematology 2018
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC6128084/
https://ncbi.nlm.nih.gov/pubmed/29991557
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2018-01-829036
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