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Glutamine via α-ketoglutarate dehydrogenase provides succinyl-CoA for heme synthesis during erythropoiesis
During erythroid differentiation, the erythron must remodel its protein constituents so that the mature red cell contains hemoglobin as the chief cytoplasmic protein component. For this, ∼10(9) molecules of heme must be synthesized, consuming 10(10) molecules of succinyl-CoA. It has long been assume...
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| Pubblicato in: | Blood |
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| Autori principali: | , , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
American Society of Hematology
2018
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6128084/ https://ncbi.nlm.nih.gov/pubmed/29991557 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2018-01-829036 |
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