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Noncanonical coproporphyrin-dependent bacterial heme biosynthesis pathway that does not use protoporphyrin
It has been generally accepted that biosynthesis of protoheme (heme) uses a common set of core metabolic intermediates that includes protoporphyrin. Herein, we show that the Actinobacteria and Firmicutes (high-GC and low-GC Gram-positive bacteria) are unable to synthesize protoporphyrin. Instead, th...
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| Publicado no: | Proc Natl Acad Sci U S A |
|---|---|
| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4343137/ https://ncbi.nlm.nih.gov/pubmed/25646457 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1416285112 |
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