Noncanonical coproporphyrin-dependent bacterial heme biosynthesis pathway that does not use protoporphyrin

It has been generally accepted that biosynthesis of protoheme (heme) uses a common set of core metabolic intermediates that includes protoporphyrin. Herein, we show that the Actinobacteria and Firmicutes (high-GC and low-GC Gram-positive bacteria) are unable to synthesize protoporphyrin. Instead, th...

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Detaylı Bibliyografya
Yayımlandı:Proc Natl Acad Sci U S A
Asıl Yazarlar: Dailey, Harry A., Gerdes, Svetlana, Dailey, Tamara A., Burch, Joseph S., Phillips, John D.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: National Academy of Sciences 2015
Konular:
Biological Sciences
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4343137/
https://ncbi.nlm.nih.gov/pubmed/25646457
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1416285112
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