mitoTev‐TALE: a monomeric DNA editing enzyme to reduce mutant mitochondrial DNA levels

Pathogenic mitochondrial DNA (mtDNA) mutations often co‐exist with wild‐type molecules (mtDNA heteroplasmy). Phenotypes manifest when the percentage of mutant mtDNA is high (70–90%). Previously, our laboratory showed that mitochondria‐targeted transcription activator‐like effector nucleases (mitoTAL...

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Bibliographic Details
Published in:EMBO Mol Med
Main Authors: Pereira, Claudia V, Bacman, Sandra R, Arguello, Tania, Zekonyte, Ugne, Williams, Sion L, Edgell, David R, Moraes, Carlos T
Format: Artigo
Language:Inglês
Published: John Wiley and Sons Inc. 2018
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Reports
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6127889/
https://ncbi.nlm.nih.gov/pubmed/30012581
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/emmm.201708084
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