PD-1 Expression on Mycobacterium tuberculosis-Specific CD4 T Cells Is Associated With Bacterial Load in Human Tuberculosis

Persistent antigen stimulation in chronic infections has been associated with antigen-specific T cell dysfunction and upregulation of inhibitory receptors, including programmed cell death protein 1 (PD-1). Pulmonary tuberculosis (TB) disease is characterized by high levels of Mycobacterium tuberculo...

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Detalhes bibliográficos
Publicado no:Front Immunol
Main Authors: Day, Cheryl L., Abrahams, Deborah A., Bunjun, Rubina, Stone, Lynnett, de Kock, Marwou, Walzl, Gerhard, Wilkinson, Robert J., Burgers, Wendy A., Hanekom, Willem A.
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2018
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6127207/
https://ncbi.nlm.nih.gov/pubmed/30233588
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2018.01995
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