Patients with Tuberculosis Disease Have Mycobacterium tuberculosis-Specific CD8 T Cells with a Pro-Apoptotic Phenotype and Impaired Proliferative Capacity, Which Is Not Restored following Treatment

CD8 T cells play a critical role in control of chronic viral infections; however, the role of these cells in containing persistent bacterial infections, such as those caused by Mycobacterium tuberculosis (Mtb), is less clear. We assessed the phenotype and functional capacity of CD8 T cells specific...

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Detalhes bibliográficos
Main Authors: Day, Cheryl L., Moshi, Noella D., Abrahams, Deborah A., van Rooyen, Michele, O'rie, Terrence, de Kock, Marwou, Hanekom, Willem A.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2014
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3989259/
https://ncbi.nlm.nih.gov/pubmed/24740417
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0094949
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