Targeting the FKBP51/GR/Hsp90 Complex to Identify Functionally Relevant Treatments for Depression and PTSD

Genetic and epigenetic alterations in FK506-binding protein 5 (FKBP5) have been associated with increased risk for psychiatric disorders, including post-traumatic stress disorder (PTSD). Some of these common variants can increase the expression of FKBP5, the gene that encodes FKBP51. Excess FKBP51 p...

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Udgivet i:ACS Chem Biol
Main Authors: Sabbagh, Jonathan J., Cordova, Ricardo A., Zheng, Dali, Marrero, Marangelie-Criado, Lemus, Andrea, Li, Pengfei, Baker, Jeremy D., Nordhues, Bryce A., Darling, April L., Martinez-Licha, Carlos, Rutz, Daniel A., Patel, Shreya, Buchner, Johannes, Leahy, James W., Koren, John, Dickey, Chad A., Blair, Laura J.
Format: Artigo
Sprog:Inglês
Udgivet: 2018
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6126901/
https://ncbi.nlm.nih.gov/pubmed/29893552
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschembio.8b00454
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