RNF169 limits 53BP1 deposition at DSBs to stimulate single-strand annealing repair

Unrestrained 53BP1 activity at DNA double-strand breaks (DSBs) hampers DNA end resection and upsets DSB repair pathway choice. RNF169 acts as a molecular rheostat to limit 53BP1 deposition at DSBs, but how this fine balance translates to DSB repair control remains undefined. In striking contrast to...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: An, Liwei, Dong, Chao, Li, Junshi, Chen, Jie, Yuan, Jingsong, Huang, Jun, Chan, Kui Ming, Yu, Cheng-han, Huen, Michael S. Y.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2018
Assuntos:
PNAS Plus
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6126738/
https://ncbi.nlm.nih.gov/pubmed/30104380
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1804823115
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