The consequences of cavity creation on the folding landscape of a repeat protein depend upon context

The effect of introducing internal cavities on protein native structure and global stability has been well documented, but the consequences of these packing defects on folding free-energy landscapes have received less attention. We investigated the effects of cavity creation on the folding landscape...

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Veröffentlicht in:Proc Natl Acad Sci U S A
Hauptverfasser: Jenkins, Kelly A., Fossat, Martin J., Zhang, Siwen, Rai, Durgesh K., Klein, Sean, Gillilan, Richard, White, Zackary, Gerlich, Grayson, McCallum, Scott A., Winter, Roland, Gruner, Sol M., Barrick, Doug, Royer, Catherine A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2018
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PNAS Plus
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6126725/
https://ncbi.nlm.nih.gov/pubmed/30104366
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1807379115
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