The consequences of cavity creation on the folding landscape of a repeat protein depend upon context

The effect of introducing internal cavities on protein native structure and global stability has been well documented, but the consequences of these packing defects on folding free-energy landscapes have received less attention. We investigated the effects of cavity creation on the folding landscape...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Jenkins, Kelly A., Fossat, Martin J., Zhang, Siwen, Rai, Durgesh K., Klein, Sean, Gillilan, Richard, White, Zackary, Gerlich, Grayson, McCallum, Scott A., Winter, Roland, Gruner, Sol M., Barrick, Doug, Royer, Catherine A.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2018
Assuntos:
PNAS Plus
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6126725/
https://ncbi.nlm.nih.gov/pubmed/30104366
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1807379115
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