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An intestinal stem cell niche in Apc mutated neoplasia targetable by CtBP inhibition
C-terminal binding protein 2 (CtBP2) drives intestinal polyposis in the Apc (min) mouse model of human Familial Adenomatous Polyposis. As CtBP2 is targetable by an inhibitor of its dehydrogenase domain, understanding CtBP2’s role in adenoma formation is necessary to optimize CtBP-targeted therapies...
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| 出版年: | Oncotarget |
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| 主要な著者: | , , , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Impact Journals LLC
2018
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6126694/ https://ncbi.nlm.nih.gov/pubmed/30197752 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.25784 |
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