Spatially Resolved Proteome Mapping of Laser Capture Microdissected Tissue with Automated Sample Transfer to Nanodroplets

Current mass spectrometry (MS)-based proteomics approaches are ineffective for mapping protein expression in tissue sections with high spatial resolution because of the limited overall sensitivity of conventional workflows. Here we report an integrated and automated method to advance spatially resol...

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Detalhes bibliográficos
Publicado no:Mol Cell Proteomics
Main Authors: Zhu, Ying, Dou, Maowei, Piehowski, Paul D., Liang, Yiran, Wang, Fangjun, Chu, Rosalie K., Chrisler, William B., Smith, Jordan N., Schwarz, Kaitlynn C., Shen, Yufeng, Shukla, Anil K., Moore, Ronald J., Smith, Richard D., Qian, Wei-Jun, Kelly, Ryan T.
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Biochemistry and Molecular Biology 2018
Assuntos:
Technological Innovation and Resources
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6126383/
https://ncbi.nlm.nih.gov/pubmed/29941660
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/mcp.TIR118.000686
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