Koumine Decreases Astrocyte-Mediated Neuroinflammation and Enhances Autophagy, Contributing to Neuropathic Pain From Chronic Constriction Injury in Rats

Koumine, an indole alkaloid, is a major bioactive component of Gelsemium elegans. Previous studies have demonstrated that koumine has noticeable anti-inflammatory and analgesic effects in inflammatory and neuropathic pain (NP) models, but the mechanisms involved are not well understood. This study w...

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Bibliografiske detaljer
Udgivet i:Front Pharmacol
Main Authors: Jin, Gui-lin, Yue, Rong-cai, He, Sai-di, Hong, Li-mian, Xu, Ying, Yu, Chang-xi
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2018
Fag:
Pharmacology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6125371/
https://ncbi.nlm.nih.gov/pubmed/30214411
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2018.00989
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