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Koumine enhances spinal cord 3α-hydroxysteroid oxidoreductase expression and activity in a rat model of neuropathic pain

BACKGROUND: Koumine is an alkaloid monomer found abundantly in Gelsemium plants. It has been shown to reverse thermal hyperalgesia and mechanical allodynia induced by sciatic nerve chronic constriction injury (CCI) in rats in a dose-dependent manner. Interestingly, this effect is mediated by elevate...

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Foilsithe in:Mol Pain
Main Authors: Qiu, Hong-Qiang, Xu, Ying, Jin, Gui-Lin, Yang, Jian, Liu, Ming, Li, Su-Ping, Yu, Chang-Xi
Formáid: Artigo
Teanga:Inglês
Foilsithe: BioMed Central 2015
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4529695/
https://ncbi.nlm.nih.gov/pubmed/26255228
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12990-015-0050-1
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