Sphingosine Kinases promote IL-17 expression in human T lymphocytes

Sphingosine 1-phosphate (S1P) has a role in many cellular processes. S1P is involved in cell growth and apoptosis, regulation of cell trafficking, production of cytokines and chemokines. The kinases SphK1 and SphK2 (SphKs) phosphorilate Sphingosine (Sph) to S1P and several phosphatases revert S1P to...

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Published in:Sci Rep
Main Authors: Barra, Giusi, Lepore, Alessio, Gagliardi, Miriam, Somma, Domenico, Matarazzo, Maria Rosaria, Costabile, Francesca, Pasquale, Giuseppe, Mazzoni, Alessio, Gallo, Carmela, Nuzzo, Genoveffa, Annunziato, Francesco, Fontana, Angelo, Leonardi, Antonio, De Palma, Raffaele
Format: Artigo
Language:Inglês
Published: Nature Publishing Group UK 2018
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6125344/
https://ncbi.nlm.nih.gov/pubmed/30185808
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-31666-1
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