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SMAD4 suppresses WNT-driven dedifferentiation and oncogenesis in the differentiated gut epithelium

The cell-of-origin of colon cancer is typically thought to be the resident somatic stem cells, which are immortal and escape the continual cellular turnover characteristic of the intestinal epithelium. However, recent studies have identified certain conditions in which differentiated cells can acqui...

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Détails bibliographiques
Publié dans:Cancer Res
Auteurs principaux: Perekatt, Ansu O., Shah, Pooja P., Cheung, Shannon, Jariwala, Nidhi, Wu, Alex, Gandhi, Vishal, Kumar, Namit, Feng, Qiang, Patel, Neeket, Chen, Lei, Joshi, Shilpy, Zhou, Anbo, Taketo, M. Mark, Xing, Jinchuan, White, Eileen, Gao, Nan, Gatza, Michael L., Verzi, Michael P.
Format: Artigo
Langue:Inglês
Publié: 2018
Sujets:
Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6125228/
https://ncbi.nlm.nih.gov/pubmed/29986996
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-18-0043
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