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Hypoxic Preconditioning of Mesenchymal Stem Cells with Subsequent Spheroid Formation Accelerates Repair of Segmental Bone Defects

Cell-based approaches for musculoskeletal tissue repair are limited by poor cell survival and engraftment. Short-term hypoxic preconditioning of mesenchymal stem cells (MSCs) can prolong cell viability in vivo, while the aggregation of MSCs into spheroids increases cell survival, trophic factor secr...

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Detalhes bibliográficos
Publicado no:Stem Cells
Main Authors: Ho, Steve S., Hung, Ben P., Heyrani, Nasser, Lee, Mark A., Leach, J. Kent
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6125201/
https://ncbi.nlm.nih.gov/pubmed/29968952
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/stem.2853
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